Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003319)
Formula
CYP2C19 ...
SVG example
Reactant 4-hydroxynimesulideM1 Product Nimesulide metabolite M2
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003328 Nimesulide 4-hydroxynimesulideM1 Unclear Nimesulide [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003318 4-hydroxynimesulideM1 Nimesulide metabolite M5A,5B Unclear Nimesulide [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003320 Nimesulide metabolite M5A,5B Nimesulide metabolite M2 Unclear Nimesulide [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003325 Nimesulide metabolite M2 Nimesulide metabolite M3 Unclear Nimesulide [1]
References
1 Neutrophil- and myeloperoxidase-mediated metabolism of reduced nimesulide: evidence for bioactivation Chem Res Toxicol. 2010 Nov 15;23(11):1691-700. doi: 10.1021/tx1001496.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.