Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003546)
Formula
CYP3A4 ...
SVG example
Hydroxylation
Reactant Nintedanib esylate Product Nintedanib metabolite M8
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003544 Nintedanib esylate Nintedanib metabolite M12 Unclear Nintedanib esylate [1]
MR003547 Nintedanib esylate Nintedanib metabolite M13 Unclear Nintedanib esylate [1]
MR003537 Nintedanib esylate Nintedanib metabolite M5 Oxidation - Demethylation Nintedanib esylate [1]
MR003531 Nintedanib esylate Nintedanib metabolite M6 Oxidation - Demethylation Nintedanib esylate [1]
MR003543 Nintedanib esylate Nintedanib metabolite M7 Conjugation - Glucuronidation Nintedanib esylate [1]
MR003545 Nintedanib esylate Nintedanib metabolite M9 Unclear Nintedanib esylate [1]
References
1 Metabolic pro?ling of tyrosine kinase inhibitor nintedanib using metabolomics J Pharm Biomed Anal. 2020 Feb 20;180:113045. doi: 10.1016/j.jpba.2019.113045.

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