Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003761)
Formula Reactant LY-450139 Product LY-2484595 Metabolite M4
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003759 LY-450139 LY-2484595 Metabolite M2 Unclear LY-450139 [1]
MR003762 LY-450139 LY-2484595 Metabolite M3 Oxidation - Benzylic hydroxylation LY-450139 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003753 LY-2484595 LY-2484595 Metabolite M4 Oxidation - Oxidationn LY-2484595 [2]
References
1 Disposition and metabolism of semagacestat, a {gamma}-secretase inhibitor, in humans. Drug Metab Dispos. 2010 Apr;38(4):554-65.
2 Evacetrapib: in?vitro and clinical disposition, metabolism, excretion, and assessment of drug interaction potential with strong CYP3A and CYP2C8 inhibitors

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