Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM003320)
DM Name	LY-2484595 Metabolite M3

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 1A2 (CYP1A2)	DME0003	LY-450139	Oxidation - Benzylic hydroxylation	LY-450139	[1]
Cytochrome P450 2A6 (CYP2A6)	DME0005	LY-450139	Oxidation - Benzylic hydroxylation	LY-450139	[1]
Cytochrome P450 2B6 (CYP2B6)	DME0020	LY-450139	Oxidation - Benzylic hydroxylation	LY-450139	[1]
Cytochrome P450 2C8 (CYP2C8)	DME0018	LY-450139	Oxidation - Benzylic hydroxylation	LY-450139	[1]
Cytochrome P450 2C9 (CYP2C9)	DME0019	LY-450139	Oxidation - Benzylic hydroxylation	LY-450139	[1]
Cytochrome P450 2D6 (CYP2D6)	DME0009	LY-450139	Oxidation - Benzylic hydroxylation	LY-450139	[1]
Cytochrome P450 2E1 (CYP2E1)	DME0013	LY-450139	Oxidation - Benzylic hydroxylation	LY-450139	[1]
Lauric acid omega-hydroxylase (CYP4A11)	DME0029	LY-450139	Oxidation - Benzylic hydroxylation	LY-450139	[1]
Mephenytoin 4-hydroxylase (CYP2C19)	DME0021	LY-450139	Oxidation - Benzylic hydroxylation	LY-450139	[1]

Full List of Drug(s) That Produce This DM By Metabolism
LY-2484595		DR1878	Phase 3		Myocardial infarction

LY-450139		DR1888	Phase 3		Alzheimer disease

References
1	Disposition and metabolism of semagacestat, a {gamma}-secretase inhibitor, in humans. Drug Metab Dispos. 2010 Apr;38(4):554-65.

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