Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003762)
Formula Reactant LY-450139 Product LY-2484595 Metabolite M3
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2A6 (CYP2A6) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 2E1 (CYP2E1) DME Info
Lauric acid omega-hydroxylase (CYP4A11) DME Info
Metabolic Type Oxidation - Benzylic hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003759 LY-450139 LY-2484595 Metabolite M2 Unclear LY-450139 [1]
MR003761 LY-450139 LY-2484595 Metabolite M4 Unclear LY-450139 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003752 LY-2484595 LY-2484595 Metabolite M3 Oxidation - Oxidationn LY-2484595 [2]
References
1 Disposition and metabolism of semagacestat, a {gamma}-secretase inhibitor, in humans. Drug Metab Dispos. 2010 Apr;38(4):554-65.
2 Evacetrapib: in?vitro and clinical disposition, metabolism, excretion, and assessment of drug interaction potential with strong CYP3A and CYP2C8 inhibitors

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