Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004714)
Formula
SVG example
N-dealkylation
Reactant Metoprolol succinate Product Deisopropylmetoprolol
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004707 Metoprolol succinate Alpha-Hydroxymetoprolol Oxidation - Hydrolyzationn Metoprolol succinate [1]
MR004715 Metoprolol succinate H104/83 Unclear Metoprolol succinate [2]
MR004711 Metoprolol succinate H105/22 Unclear Metoprolol succinate [2]
MR004713 Metoprolol succinate O-Demethylmetoprolol Oxidation - O-dealkylation Metoprolol succinate [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004723 Metoprolol tartrate Deisopropylmetoprolol Oxidation - N-dealkylation Metoprolol tartrate [3]
References
1 DrugBank(Pharmacology-Metabolism):Metoprolol succinate
2 Metabolism of metoprolol in the rat in vitro and in vivo
3 Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.

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