Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004707)
Formula
SVG example
Hydrolyzationn
Reactant Metoprolol succinate Product Alpha-Hydroxymetoprolol
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004714 Metoprolol succinate Deisopropylmetoprolol Oxidation - N-dealkylation Metoprolol succinate [1]
MR004715 Metoprolol succinate H104/83 Unclear Metoprolol succinate [2]
MR004711 Metoprolol succinate H105/22 Unclear Metoprolol succinate [2]
MR004713 Metoprolol succinate O-Demethylmetoprolol Oxidation - O-dealkylation Metoprolol succinate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004716 Metoprolol tartrate Alpha-Hydroxymetoprolol Oxidation - Hydrolyzationn Metoprolol tartrate [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004708 Alpha-Hydroxymetoprolol H119/72 Unclear Metoprolol succinate [2]
MR004717 Alpha-Hydroxymetoprolol H119/72 Unclear Metoprolol tartrate [2]
References
1 Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.
2 Metabolism of metoprolol in the rat in vitro and in vivo

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