Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004713)
Formula
CYP2D6 ...
SVG example
O-dealkylation
Reactant Metoprolol succinate Product O-Demethylmetoprolol
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - O-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004707 Metoprolol succinate Alpha-Hydroxymetoprolol Oxidation - Hydrolyzationn Metoprolol succinate [1]
MR004714 Metoprolol succinate Deisopropylmetoprolol Oxidation - N-dealkylation Metoprolol succinate [2]
MR004715 Metoprolol succinate H104/83 Unclear Metoprolol succinate [3]
MR004711 Metoprolol succinate H105/22 Unclear Metoprolol succinate [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004722 Metoprolol tartrate O-Demethylmetoprolol Oxidation - O-dealkylation Metoprolol tartrate [2]
References
1 DrugBank(Pharmacology-Metabolism):Metoprolol succinate
2 Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.
3 Metabolism of metoprolol in the rat in vitro and in vivo

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