Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004723)
Formula
SVG example
N-dealkylation
Reactant Metoprolol tartrate Product Deisopropylmetoprolol
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004716 Metoprolol tartrate Alpha-Hydroxymetoprolol Oxidation - Hydrolyzationn Metoprolol tartrate [1]
MR004724 Metoprolol tartrate H104/83 Unclear Metoprolol tartrate [1]
MR004720 Metoprolol tartrate H105/22 Unclear Metoprolol tartrate [1]
MR004722 Metoprolol tartrate O-Demethylmetoprolol Oxidation - O-dealkylation Metoprolol tartrate [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004714 Metoprolol succinate Deisopropylmetoprolol Oxidation - N-dealkylation Metoprolol succinate [2]
References
1 Metabolism of metoprolol in the rat in vitro and in vivo
2 Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.

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