Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013453)
Formula
SVG example
Reactant Etoperidone Product 1-(3-chlorophenyl) piperazine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013469 Etoperidone 1-(3-chlorophenyl) piperazine (M22) Oxidation - N-dealkylation Etoperidone [1]
MR013460 Etoperidone Etoperidone Metabolite M12 Hydrolysis - Hydrolysis Etoperidone [1]
MR013465 Etoperidone Etoperidone Metabolite M19 Oxidation - Oxidationn Etoperidone [1]
MR013442 Etoperidone Etoperidone Metabolite M2 Oxidation - Oxidationn Etoperidone [1], [2]
MR013466 Etoperidone Etoperidone Metabolite M20 Oxidation - Oxidationn Etoperidone [1]
MR013467 Etoperidone Etoperidone Metabolite M21 Oxidation - Oxidationn Etoperidone [1]
MR013468 Etoperidone Etoperidone Metabolite M4 Oxidation - Aromatic hydroxylation Etoperidone [1]
MR013451 Etoperidone Etoperidone Metabolite M5 Oxidation - Hydrolyzationn Etoperidone [1], [2]
MR013458 Etoperidone Etoperidone Metabolite M6 Oxidation - N-dealkylation Etoperidone [1]
MR013455 Etoperidone Etoperidone Metabolite N6 Unclear Etoperidone [1]
MR013464 Etoperidone N-oxide etoperidone Oxidation - Oxidationn Etoperidone [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004891 Nefazodone M-Chlorophenylpiperazine Unclear Nefazodone [3]
MR002444 Trazodone hydrochloride M-chlorophenylpiperazine Oxidation - N-Dealkylation Trazodone hydrochloride [4]
MR004886 Hydroxynefazodone M-Chlorophenylpiperazine Unclear Nefazodone [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013454 1-(3-chlorophenyl) piperazine Etoperidone Metabolite N9 Oxidation - N-dealkylation Etoperidone [1]
MR004887 M-Chlorophenylpiperazine p-hydroxy-mCPP Unclear Nefazodone [3]
References
1 Evaluation of the absorption, excretion and metabolism of [14C] etoperidone in man
2 In vitro identification of metabolic pathways and cytochrome P450 enzymes involved in the metabolism of etoperidone. Xenobiotica. 2002 Nov;32(11):949-62.
3 Clinical pharmacokinetics of nefazodone. Clin Pharmacokinet. 1997 Oct;33(4):260-75.
4 Pharmacokinetics of trazodone and its major metabolite m-chlorophenylpiperazine in plasma and brain of rats Int J Neuropsychopharmacol. 1999 Mar;2(1):17-23. doi: 10.1017/S1461145799001303.

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