Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004959)
Formula
CYP1A2 ...
SVG example
N-dealkylation
Reactant Thioridazine Product N-desmethylthioridazine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004961 Thioridazine Hydroxy-Thioridazine Unclear Thioridazine [1]
MR004957 Thioridazine Thioridazine 2-sulfoxide Oxidation - S-oxidation Thioridazine [2]
MR004960 Thioridazine Thioridazine 5-sulfoxide Oxidation - S-oxidation Thioridazine [2]
References
1 Pharmacokinetics and metabolism of thioridazine during co-administration of tricyclic antidepressants
2 Extraction of structure-activity relationship information from high-throughput screening data Curr Med Chem. 2009;16(31):4049-57. doi: 10.2174/092986709789378189.

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