Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005082)
Formula
SVG example
Oxidationn
Reactant Halothane Product Trifluoroacetic acid
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2E1 (CYP2E1) DME Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005084 Halothane 1-chloro-2,2,2-trifluoroethanide Reduction - Dehalogenation Halothane [1], [2]
MR005083 Halothane 2-chloro-1,1-difluoroethene Reduction - Dehalogenation Halothane [1], [2]
MR005081 Halothane Bromide Oxidation - Oxidationn Halothane [3]
MR005086 Halothane Chlorotrifluoroethane Reduction - Dehalogenation Halothane [2]
MR005085 Halothane Trifluoroacetyl chloride Reduction - Dehalogenation Halothane [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001231 Isoflurane Trifluoroacetic acid Unclear Isoflurane [4]
References
1 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
2 Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.
3 DrugBank(Pharmacology-Metabolism):Halothane
4 Clinical isoflurane metabolism by cytochrome P450 2E1. Anesthesiology. 1999 Mar;90(3):766-71.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.