Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005086)
Formula
CYP3A4 ...
SVG example
Dehalogenation
Reactant Halothane Product Chlorotrifluoroethane
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2A6 (CYP2A6) DME Info
Metabolic Type Reduction - Dehalogenation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005084 Halothane 1-chloro-2,2,2-trifluoroethanide Reduction - Dehalogenation Halothane [1], [2]
MR005083 Halothane 2-chloro-1,1-difluoroethene Reduction - Dehalogenation Halothane [1], [2]
MR005081 Halothane Bromide Oxidation - Oxidationn Halothane [3]
MR005082 Halothane Trifluoroacetic acid Oxidation - Oxidationn Halothane [3]
MR005085 Halothane Trifluoroacetyl chloride Reduction - Dehalogenation Halothane [2]
References
1 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
2 Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.
3 DrugBank(Pharmacology-Metabolism):Halothane

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