Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005252)
Formula
CYP2D6 ...
SVG example
N-dealkylation
Reactant Dehydrosertindole Product Norsertindole
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005254 4-hydroxy-serindole Dehydrosertindole Oxidation - Oxidationn Sertindole [1]
MR005250 5-hydroxy-serindole Dehydrosertindole Oxidation - Oxidationn Sertindole [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005251 Dehydrosertindole 3'-fluoro-4'-hydroxy-dehydro-sertindole Unclear Sertindole [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005259 Sertindole Norsertindole Oxidation - N-dealkylation Sertindole [1], [2]
References
1 Metabolism of sertindole: identification of the metabolites in the rat and dog, and species comparison of liver microsomal metabolism
2 Sertindole : a review of its use in schizophrenia

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