Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005259)
Formula
CYP2D6 ...
SVG example
N-dealkylation
Reactant Sertindole Product Norsertindole
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005260 Sertindole 3'-fluoro-4'-hydroxy-sertindole Unclear Sertindole [1]
MR005253 Sertindole 4-hydroxy-serindole Oxidation - Hydrolyzationn Sertindole [1]
MR005249 Sertindole 5-hydroxy-serindole Oxidation - Hydrolyzationn Sertindole [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005252 Dehydrosertindole Norsertindole Oxidation - N-dealkylation Sertindole [1]
References
1 Metabolism of sertindole: identification of the metabolites in the rat and dog, and species comparison of liver microsomal metabolism

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