Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005254)
Formula
CYP2D6 ...
SVG example
Oxidationn
Reactant 4-hydroxy-serindole Product Dehydrosertindole
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005253 Sertindole 4-hydroxy-serindole Oxidation - Hydrolyzationn Sertindole [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005255 4-hydroxy-serindole 4-0x0-sertindole Oxidation - Oxidationn Sertindole [1]
MR005258 4-hydroxy-serindole 4.5 Dihydroxy-serfindo Oxidation - Hydrolyzationn Sertindole [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005250 5-hydroxy-serindole Dehydrosertindole Oxidation - Oxidationn Sertindole [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005251 Dehydrosertindole 3'-fluoro-4'-hydroxy-dehydro-sertindole Unclear Sertindole [1]
MR005252 Dehydrosertindole Norsertindole Oxidation - N-dealkylation Sertindole [1]
References
1 Metabolism of sertindole: identification of the metabolites in the rat and dog, and species comparison of liver microsomal metabolism

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