Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005368)
Formula
CYP2C8 ...
SVG example
Aliphatic hydroxylation
Reactant Lauric acid Product 12-Hydroxydodecanoic Acid
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 2E1 (CYP2E1) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Metabolic Type Oxidation - Aliphatic hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005371 Lauric acid 11-hydroxylauric acid Oxidation - Hydrolyzationn Lauric acid [1]
MR005372 Lauric acid 2-hydroxylauric acid Oxidation - Hydrolyzationn Lauric acid [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005369 12-Hydroxydodecanoic Acid 12,12-Dihydroxydodecanoic Acid Oxidation - Oxidationn Lauric acid [2], [1]
References
1 Cytochrome P450 4A11 inhibition assays based on characterization of lauric acid metabolites
2 The omega-hydroxlyation of lauric acid: oxidation of 12-hydroxlauric acid to dodecanedioic acid by a purified recombinant fusion protein containing P450 4A1 and NADPH-P450 reductase

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