Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005388)
Formula
CYP2B6 ...
SVG example
Oxidationn
Reactant PF-04965842 Product Abrocitinib M4 metabolite
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2B6 (CYP2B6) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005393 PF-04965842 Abrocitinib M1 metabolite Oxidation - Oxidationn PF-04965842 [1]
MR005397 PF-04965842 Abrocitinib M2 metabolite Unclear PF-04965842 [2]
MR005400 PF-04965842 Abrocitinib M3 metabolite Unclear PF-04965842 [2]
MR005403 PF-04965842 Abrocitinib M5 metabolite Unclear PF-04965842 [2]
MR012168 PF-04965842 PF-04965842 Metabolites M1 Unclear - Unclear PF-04965842 [2]
MR012178 PF-04965842 PF-04965842 Metabolites M2 Unclear - Unclear PF-04965842 [3]
MR012181 PF-04965842 PF-04965842 Metabolites M3 Unclear - Unclear PF-04965842 [3]
MR012173 PF-04965842 PF-04965842 Metabolites M4 Unclear - Unclear PF-04965842 [3]
MR012184 PF-04965842 PF-04965842 Metabolites M5 Unclear - Unclear PF-04965842 [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005391 Abrocitinib M4 metabolite 2XOH Unclear PF-04965842 [2]
MR005389 Abrocitinib M4 metabolite Abrocitinib M8 metabolite Unclear PF-04965842 [2]
References
1 Validation of enantioseparation and quantitation of an active metabolite of abrocitinib in human plasma
2 The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Abrocitinib, a Selective Janus Kinase Inhibitor, in Humans
3 Safety, pharmacokinetics and pharmacodynamics of four-hour intravenous infusions of eritoran in healthy Japanese and Caucasian men

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