Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006055)
Formula
CYP1A2 ...
SVG example
Oxidationn
Reactant HOE-239 Product Fexinidazole Sulfone M1
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Dimethylaniline oxidase 3 (FMO3) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005476 Fexinidazole Fexinidazole sulfoxide metabolite (M1) Oxidation - Oxidationn Fexinidazole [1], [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006056 Fexinidazole Sulfone M1 Fexinidazole Sulfone M2 Oxidation - Oxidationn HOE-239 [1]
MR005477 Fexinidazole sulfoxide metabolite (M1) Fexinidazole sulfone metabolite (M2) Oxidation - Oxidationn Fexinidazole [1], [2]
References
1 Determination of an optimal dosing regimen for fexinidazole, a novel oral drug for the treatment of human African trypanosomiasis: first-in-human studies
2 Fexinidazole--a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness. PLoS Negl Trop Dis. 2010 Dec 21;4(12):e923.

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