Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006131)
Formula
SVG example
N-dealkylation
Reactant KB-2796 Product 1-[Bis(4-fluorophenyl)methyl]piperazine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006133 KB-2796 Lomerizine M3 Oxidation - Hydrolyzationn KB-2796 [1]
MR006132 KB-2796 Lomerizine M5 Oxidation - O-demethylation KB-2796 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013905 Flunarizine Flunarizine M1 Oxidation - N-desalkylation Flunarizine [2]
References
1 [Metabolism of lomerizine hydrochloride (KB-2796) in rats]
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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