Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013905)
Formula
CYP2C9 ...
SVG example
N-desalkylation
Reactant Flunarizine Product Flunarizine M1
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2A6 (CYP2A6) DME Info
Cytochrome P450 1A1 (CYP1A1) DME Info
Metabolic Type Oxidation - N-desalkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013906 Flunarizine Flunarizine M2 Oxidation - Hydroxylation Flunarizine [1]
MR013907 Flunarizine Flunarizine M3 Oxidation - N-desalkylation Flunarizine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006131 KB-2796 1-[Bis(4-fluorophenyl)methyl]piperazine Oxidation - N-dealkylation KB-2796 [2]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 [Metabolism of lomerizine hydrochloride (KB-2796) in rats]

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