Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009636)
Formula
CYP2C8 ...
SVG example
Hydroxylation
Reactant Tretinoin Product 18-OH-RA
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 3A7 (CYP3A7) DME Info
Cytochrome P450 2C18 (CYP2C18) DME Info
Lauric acid omega-hydroxylase (CYP4A11) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Cytochrome P450 2A6 (CYP2A6) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009631 Tretinoin 13-cis RA Other reaction - Isomerization Tretinoin [1], [2]
MR009637 Tretinoin 3,4-Didehydroretinoic acid Oxidation - Oxidation Tretinoin [3]
MR009626 Tretinoin 4-Hydroxyretinoic acid Oxidation - 4-hydroxylation Tretinoin [4], [1]
MR009629 Tretinoin 5,6-epoxy-RA Oxidation - Ring epoxidation Tretinoin [2], [2], [4]
MR009634 Tretinoin 9-cis RA Other reaction - Isomerization Tretinoin [1], [2]
MR009638 Tretinoin Retinotaurine Oxidation - Oxidation Tretinoin [3]
MR009639 Tretinoin Retinoyl beta-glucuronide Conjugation - Glucuronidation Tretinoin [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006381 NSC-122758 All-trans-18-Hydroxyretinoic acid Oxidation - Hydrolyzationn NSC-122758 [4], [5]
References
1 Human cytochrome P450s involved in the metabolism of 9-cis- and 13-cis-retinoic acids
2 Retinoic acid metabolism and mechanism of action: a review
3 Clinical pharmacokinetics of tretinoin
4 Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. Mol Pharmacol. 2000 Dec;58(6):1341-8.
5 CYP26C1 is a hydroxylase of multiple active retinoids and interacts with cellular retinoic acid binding proteins. Mol Pharmacol. 2018 May;93(5):489-503.

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