Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006472)
Formula Reactant TAK-875 Product TAK-875 Metabolite M-I
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006475 TAK-875 Fasiglifam-G Conjugation - Conjugation TAK-875 [1]
MR006474 TAK-875 Fasiglifam-Tau Unclear TAK-875 [1]
MR006476 TAK-875 T-167642 Unclear TAK-875 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006473 TAK-875 Metabolite M-I TAK-875 Metabolite M-I-G Conjugation - Conjugation TAK-875 [1]
References
1 Disposition and metabolism of the G protein-coupled receptor 40 agonist TAK-875 (fasiglifam) in rats, dogs, and humans. Xenobiotica. 2019 Apr;49(4):433-445.

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