Details of the Metabolic Reaction (MR) | INTEDE

General Information of This Metabolic Reaction (MR) (ID: MR006490)
Formula	CYP3A4 ... Hydrolyzationn
	Reactant	WSM-3978G		Product	Cis-Hydroxy Perhexiline
	Reactant	Reactant Info		Product	Product Info
Metabolic Enzyme	Cytochrome P450 3A4 (CYP3A4)					DME Info
Metabolic Enzyme	Cytochrome P450 2B6 (CYP2B6)					DME Info
Metabolic Type	Oxidation - Hydrolyzationn

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR006491	WSM-3978G	Monohydroxyperhexiline	Oxidation - Hydrolyzationn	WSM-3978G	[1]
MR006492	WSM-3978G	Trans-hydroxyperhexilline	Oxidation - Aliphatic hydroxylation	WSM-3978G	[1]

References
1	CYP2B6, CYP2D6, and CYP3A4 catalyze the primary oxidative metabolism of perhexiline enantiomers by human liver microsomes. Drug Metab Dispos. 2007 Jan;35(1):128-38.

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