Details of the Metabolic Reaction (MR) | INTEDE

General Information of This Metabolic Reaction (MR) (ID: MR006491)
Formula	CYP3A4 ... Hydrolyzationn
	Reactant	WSM-3978G		Product	Monohydroxyperhexiline
	Reactant	Reactant Info		Product	Product Info
Metabolic Enzyme	Cytochrome P450 3A4 (CYP3A4)					DME Info
	Cytochrome P450 2B6 (CYP2B6)					DME Info
	Cytochrome P450 2D6 (CYP2D6)					DME Info
Metabolic Type	Oxidation - Hydrolyzationn

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR006490	WSM-3978G	Cis-Hydroxy Perhexiline	Oxidation - Hydrolyzationn	WSM-3978G	[1]
MR006492	WSM-3978G	Trans-hydroxyperhexilline	Oxidation - Aliphatic hydroxylation	WSM-3978G	[1]

References
1	CYP2B6, CYP2D6, and CYP3A4 catalyze the primary oxidative metabolism of perhexiline enantiomers by human liver microsomes. Drug Metab Dispos. 2007 Jan;35(1):128-38.

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