General Information of This Metabolic Reaction (MR) (ID: MR006491)
Formula
CYP3A4 ...
SVG example
Hydrolyzationn
Reactant WSM-3978G Product Monohydroxyperhexiline
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006490 WSM-3978G Cis-Hydroxy Perhexiline Oxidation - Hydrolyzationn WSM-3978G [1]
MR006492 WSM-3978G Trans-hydroxyperhexilline Oxidation - Aliphatic hydroxylation WSM-3978G [1]
References
1 CYP2B6, CYP2D6, and CYP3A4 catalyze the primary oxidative metabolism of perhexiline enantiomers by human liver microsomes. Drug Metab Dispos. 2007 Jan;35(1):128-38.

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