Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006580)
Formula
SVG example
Aliphatic hydroxylation
Reactant Clomipramine hydrochloride Product 10-OH-clomipramine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Aliphatic hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006571 Clomipramine hydrochloride 2-hydroxyclomipramine Oxidation - 2-hydroxylation Clomipramine hydrochloride [1]
MR006574 Clomipramine hydrochloride 8-hydroxyclomipramine Oxidation - 8-hydroxylation Clomipramine hydrochloride [2]
MR006579 Clomipramine hydrochloride 8-OH-clomipramine Oxidation - Aromatic hydroxylation Clomipramine hydrochloride [1]
MR006578 Clomipramine hydrochloride Clomipramine N-oxide Oxidation - Oxidationn Clomipramine hydrochloride [2]
MR006567 Clomipramine hydrochloride Desmethylclomipramine Oxidation - N-demethylation Clomipramine hydrochloride [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009013 Clomipramine 10-OH-clomipramine Oxidation - Aliphatic hydroxylation Clomipramine [4]
References
1 Determination of clomipramine or imipramine and their mono-demethylated metabolites in human blood or plasma by high-performance liquid chromatography
2 Metabolism of clomipramine in a Japanese psychiatric population: hydroxylation, desmethylation, and glucuronidation
3 Population pharmacokinetics of clomipramine, desmethylclomipramine, and hydroxylated metabolites in patients with depression receiving chronic treatment: model evaluation
4 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.

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