Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009013)
Formula
SVG example
Aliphatic hydroxylation
Reactant Clomipramine Product 10-OH-clomipramine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Aliphatic hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009001 Clomipramine 2-hydroxyclomipramine Oxidation - 2-hydroxylation Clomipramine [1]
MR009005 Clomipramine 8-hydroxyclomipramine Oxidation - 8-hydroxylation Clomipramine [1]
MR009012 Clomipramine 8-OH-clomipramine Oxidation - Aromatic hydroxylation Clomipramine [1]
MR009011 Clomipramine Clomipramine N-oxide Unclear - Unclear Clomipramine [2]
MR009009 Clomipramine Desmethylclomipramine Oxidation - N-demethylation Clomipramine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006580 Clomipramine hydrochloride 10-OH-clomipramine Oxidation - Aliphatic hydroxylation Clomipramine hydrochloride [3]
References
1 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
2 DrugBank(Pharmacology-Metabolism):Clomipramine
3 Metabolism of clomipramine in a Japanese psychiatric population: hydroxylation, desmethylation, and glucuronidation

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