Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006661)
Formula
CYP2D6 ...
SVG example
N-demethylation
Reactant Doxepin hydrochloride Product N-desmethyldoxepin
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006668 Doxepin hydrochloride (E)-2-hydroxydoxepin Oxidation - Hydrolyzationn Doxepin hydrochloride [1]
MR006666 Doxepin hydrochloride Doxepin N-oxide Oxidation - Oxidationn Doxepin hydrochloride [2]
MR006665 Doxepin hydrochloride Formaldehyde Oxidation - N-demethylation Doxepin hydrochloride [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006662 N-desmethyldoxepin Hydroxydesmethyl doxepin Oxidation - Hydrolyzationn Doxepin hydrochloride [2]
References
1 DrugBank(Pharmacology-Metabolism):Doxepin hydrochloride
2 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.

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