Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006820)
Formula
CYP3A4 ...
SVG example
Cyclization
Reactant Sitagliptin Product Sitagliptin M2 and M5 Metabolites
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Other reaction - Cyclization
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006819 Sitagliptin Sitagliptin M1 Metabolite Conjugation - Sulfation Sitagliptin [1]
MR006817 Sitagliptin Sitagliptin M6 Metabolite Oxidation - Carbamoylation Sitagliptin [1]
References
1 Metabolism and excretion of the dipeptidyl peptidase 4 inhibitor [14C]sitagliptin in humans

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