Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006817)
Formula
CYP3A4 ...
SVG example
Carbamoylation
Reactant Sitagliptin Product Sitagliptin M6 Metabolite
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Oxidation - Carbamoylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006819 Sitagliptin Sitagliptin M1 Metabolite Conjugation - Sulfation Sitagliptin [1]
MR006820 Sitagliptin Sitagliptin M2 and M5 Metabolites Other reaction - Cyclization Sitagliptin [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006818 Sitagliptin M6 Metabolite Sitagliptin M4 Metabolite Conjugation - O-glucuronidation Sitagliptin [1]
References
1 Metabolism and excretion of the dipeptidyl peptidase 4 inhibitor [14C]sitagliptin in humans

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