Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006833)
Formula
CYP1A2 ...
SVG example
Oxidationn
Reactant Sorafenib Product Pyridostigmine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 3A7 (CYP3A7) DME Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006834 Sorafenib Pyridine N-oxide glucuronide Multi-steps Reaction - Oxidationn; glucuronidation Sorafenib [1], [2]
MR006835 Sorafenib Sorafenib beta-D-Glucuronide Conjugation - Glucuronidation Sorafenib [1]
References
1 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
2 Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: a phase I/II pharmacokinetic interaction study. Cancer Chemother Pharmacol. 2011 Nov;68(5):1111-8.

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