Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006866)
Formula Reactant Enalapril Product Enalapril demethylation
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006865 Enalapril Enalaprilat Oxidation - Hydrolyzationn Enalapril [1]
References
1 Absorption and cleavage of enalapril, a carboxyl ester prodrug, in the rat intestine: in vitro, in situ intestinal perfusion and portal vein cannulation models. Biopharm Drug Dispos. 2015 Sep;36(6):385-397.

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