Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006934)
Formula
SVG example
Oxidationn
Reactant Macitentan Product Macitentan metabolite M4
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006937 Macitentan Aprocitentan Oxidation - Depropylation Macitentan [1]
MR006941 Macitentan Macitentan metabolite M3 Hydrolysis - Hydrolysis Macitentan [1]
MR006942 Macitentan Macitentan metabolite M7 Oxidation - Hydrolyzationn Macitentan [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006935 Macitentan metabolite M4 Macitentan metabolite M5 Oxidation - Oxidationn Macitentan [1]
References
1 Clinical pharmacokinetics and pharmacodynamics of the endothelin receptor antagonist macitentan

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