Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006937)
Formula
CYP3A4 ...
SVG example
Depropylation
Reactant Macitentan Product Aprocitentan
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - Depropylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006941 Macitentan Macitentan metabolite M3 Hydrolysis - Hydrolysis Macitentan [1]
MR006934 Macitentan Macitentan metabolite M4 Oxidation - Oxidationn Macitentan [1]
MR006942 Macitentan Macitentan metabolite M7 Oxidation - Hydrolyzationn Macitentan [1]
References
1 Clinical pharmacokinetics and pharmacodynamics of the endothelin receptor antagonist macitentan

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