Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007630)
Formula
CYP2C8 ...
SVG example
Hydrolyzationn
Reactant ML-3000 Product Licofelone M4
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2J2 (CYP2J2) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007632 ML-3000 Licofelone acyl glucuronide (M1) Conjugation - Acyl glucuronidation ML-3000 [1]
MR007634 ML-3000 Licofelone M2 Oxidation - Hydrolyzationn ML-3000 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007631 Licofelone M4 Licofelone M5 Conjugation - Acyl glucuronidation ML-3000 [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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