Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008734)
Formula Reactant Arbidol Product Arbidol M5 metabolite
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Dimethylaniline oxidase 3 (FMO3) DME Info
Dimethylaniline oxidase 1 (FMO1) DME Info
Metabolic Type Multi-steps Reaction - N-demethylation; sulfoxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008727 Arbidol Arbidol M1 metabolite Oxidation - Dealkylation Arbidol [1]
MR008748 Arbidol Arbidol M10 metabolite Conjugation - Sulfate conjugation Arbidol [1]
MR008749 Arbidol Arbidol M18 metabolite Conjugation - O-glucuronidation Arbidol [1]
MR008746 Arbidol Arbidol M3-1 metabolite Multi-steps Reaction - Sulfate conjugation; sulfoxidation Arbidol [1]
MR008731 Arbidol Arbidol M3-2 metabolite Oxidation - N-demethylation Arbidol [1]
MR008737 Arbidol Arbidol M6-1 metabolite Oxidation - Sulfoxidation Arbidol [1]
MR008750 Arbidol Arbidol M6-2 metabolite Oxidation - Hydroxylation Arbidol [1]
MR008740 Arbidol Arbidol M7 metabolite Multi-steps Reaction - N-demethylation; sulfoxidation Arbidol [1]
MR008743 Arbidol Arbidol M8 metabolite Oxidation - Sulfoxidation Arbidol [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008735 Arbidol M5 metabolite Arbidol M11-2 metabolite Conjugation - Sulfate conjugation Arbidol [2]
MR008736 Arbidol M5 metabolite Arbidol M19 metabolite Conjugation - O-glucuronidation Arbidol [2]
References
1 Pharmacokinetics, metabolism, and excretion of the antiviral drug arbidol in humans
2 DrugBank(Pharmacology-Metabolism):Arbidol

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