Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008916)
Formula
SVG example
Unclear
Reactant 3,4-dihydroxyphenylacetic acid Product 3-hydroxyphenylacetic acid
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006362 SC-47945 DOPAC Unclear SC-47945 [1]
MR006627 DHPA DOPAC Unclear Dopamine hydrochloride [2]
MR001494 3,4-Dihydroxyphenylacetaldehyde (DOPAL) 3,4-dihydroxyphenylacetic acid Oxidation - Hydroxylation Levodopa [3]
MR008915 Dopamine 3,4-dihydroxyphenylacetic acid Unclear - Unclear Docarpamine [4]
MR004488 3-(3',4'-Dihydroxyphenyl)propionic acid 3'-4'-Dihydroxyphenylacetic acid Unclear VS-12343 [5]
MR003506 DOPL 3,4-dihydroxyphenylacetic acid Unclear L-phenylalanine [6]
MR004403 2-(4-Hydroxyphenyl)acetic acid (3,4-Dihydroxyphenyl)acetic acid Oxidation - Hydrolyzationn N-nonylphenol [7]
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Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006363 DOPAC HVA Unclear SC-47945 [1]
MR006365 DOPAC Sulfate conjugate of DOPAC Unclear SC-47945 [1]
MR006628 DOPAC HVA Unclear Dopamine hydrochloride [2]
MR001496 3,4-dihydroxyphenylacetic acid Homovanillic acid Conjugation - O-Methylation Levodopa [3]
MR003507 3,4-dihydroxyphenylacetic acid 3,4-Dihydroxybenzoic acid Unclear L-phenylalanine [6]
MR004494 3'-4'-Dihydroxyphenylacetic acid 3,4-Dihydroxybenzoic acid Unclear VS-12343 [5]
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Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004499 3-(3'-Hydroxyphenyl)propionic acid 3'-Hydroxyphenylacetic acid Unclear VS-12343 [5]
MR013973 3',4'-dihydroxyphenylacetic acid 3'-hydroxyphenylacetic acid Unclear Epigallocatechin gallate [8]
MR013566 3',4'-dihydroxyphenylacetic acid 3'-hydroxyphenylacetic acid Unclear Epigallocatechin gallate [8]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004492 3'-Hydroxyphenylacetic acid 3-Hydroxybenzoic acid Unclear VS-12343 [5]
MR004490 3'-Hydroxyphenylacetic acid Phenylacetic acid Unclear VS-12343 [5]
References
1 Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: the role of aldehyde dehydrogenase. Pharmacol Rev. 2007 Jun;59(2):125-50.
2 Membrane bound catechol-O-methytransferase is the dominant isoform for dopamine metabolism in PC12 cells and rat brain
3 DrugBank(Pharmacology-Metabolism)Levodopa
4 Metabolism of a new orally active dopamine prodrug, N-(N-acetyl-L-methionyl)-O,O-bis(ethoxycarbonyl)dopamine (TA-870) and dopamine after oral administration to rats and dogs
5 Biotransformation of two citrus flavanones by lactic acid bacteria in chemical defined medium
6 Catabolism of L-phenylalanine and L-tyrosine by Rhodobacter sphaeroides OU5 occurs through 3,4-dihydroxyphenylalanine Res Microbiol. 2007 Jul-Aug;158(6):506-11. doi: 10.1016/j.resmic.2007.04.008.
7 4-n-nonylphenol degradation by the genus Metarhizium with cytochrome P450 involvement
8 Absorption, metabolism, bioactivity, and biotransformation of epigallocatechin gallate

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