General Information of This Metabolic Reaction (MR) (ID: MR004403)
Formula
SVG example
Hydrolyzationn
Reactant 2-(4-Hydroxyphenyl)acetic acid Product (3,4-Dihydroxyphenyl)acetic acid
Reactant Info Product Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005864 L-tyrosine p-hydroxyphenylacetate Unclear L-tyrosine [1]
MR003838 3-(4-Hydroxyphenyl) propionic acid (4-Hydroxyphenyl) acetic acid Unclear BE-14348A [2]
MR002017 4- hydroxyphenelzine 4-hydroxyphenylacetic acid Hydrolysis - Hydrolysis Phenelzine [3]
MR002016 Phenylacetic acid 4-hydroxyphenylacetic acid Oxidation - 4-Hydroxylation Phenelzine [3]
MR013574 5-(3',4',5'-trihydroxyphenyl)valeric acid 4'-hydroxyphenylacetic acid Unclear Epigallocatechin gallate [4]
MR004501 3-(4'-Hydroxyphenyl)propionic acid 4'-Hydroxyphenylacetic acid Unclear VS-12343 [5]
MR004398 (2E)-3-(4-Hydroxyphenyl)prop-2-enoic acid 2-(4-Hydroxyphenyl)acetic acid Unclear N-nonylphenol [6]
MR004404 2-(4-Hydroxyphenyl)acetic acid 2-(4-Hydroxyphenyl)acetic acid Unclear N-nonylphenol [6]
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Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013575 4'-hydroxyphenylacetic acid 3',4'-dihydroxyphenylacetic acid Unclear Epigallocatechin gallate [4]
MR013582 4'-hydroxyphenylacetic acid 3-methoxy-4'-hydroxyphenlacetic acid Unclear Epigallocatechin gallate [4]
MR013576 4'-hydroxyphenylacetic acid 4'-hydroxybenzoic acid Unclear Epigallocatechin gallate [4]
MR004502 4'-Hydroxyphenylacetic acid 4-Hydroxybenzoic acid Unclear VS-12343 [5]
MR004399 2-(4-Hydroxyphenyl)acetic acid 1-(4-hydroxyphenyl)ethanone Unclear N-nonylphenol [6]
MR004404 2-(4-Hydroxyphenyl)acetic acid 2-(4-Hydroxyphenyl)acetic acid Unclear N-nonylphenol [6]
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Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006362 SC-47945 DOPAC Unclear SC-47945 [7]
MR006627 DHPA DOPAC Unclear Dopamine hydrochloride [8]
MR001494 3,4-Dihydroxyphenylacetaldehyde (DOPAL) 3,4-dihydroxyphenylacetic acid Oxidation - Hydroxylation Levodopa [9]
MR008915 Dopamine 3,4-dihydroxyphenylacetic acid Unclear - Unclear Docarpamine [10]
MR004488 3-(3',4'-Dihydroxyphenyl)propionic acid 3'-4'-Dihydroxyphenylacetic acid Unclear VS-12343 [5]
MR003506 DOPL 3,4-dihydroxyphenylacetic acid Unclear L-phenylalanine [11]
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Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006363 DOPAC HVA Unclear SC-47945 [7]
MR006365 DOPAC Sulfate conjugate of DOPAC Unclear SC-47945 [7]
MR006628 DOPAC HVA Unclear Dopamine hydrochloride [8]
MR008916 3,4-dihydroxyphenylacetic acid 3-hydroxyphenylacetic acid Unclear - Unclear Docarpamine [10]
MR001496 3,4-dihydroxyphenylacetic acid Homovanillic acid Conjugation - O-Methylation Levodopa [9]
MR004489 3'-4'-Dihydroxyphenylacetic acid 3'-Hydroxyphenylacetic acid Unclear VS-12343 [5]
MR003507 3,4-dihydroxyphenylacetic acid 3,4-Dihydroxybenzoic acid Unclear L-phenylalanine [11]
MR004494 3'-4'-Dihydroxyphenylacetic acid 3,4-Dihydroxybenzoic acid Unclear VS-12343 [5]
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References
1 Potent inhibitory effects of tyrosine metabolites on dihydropteridine reductase from human and sheep liver
2 High gastrointestinal permeability and local metabolism of naringenin: influence of antibiotic treatment on absorption and metabolism
3 Insights into the mechanisms of action of the MAO inhibitors phenelzine and tranylcypromine: a review J Psychiatry Neurosci. 1992 Nov;17(5):206-14.
4 Absorption, metabolism, bioactivity, and biotransformation of epigallocatechin gallate
5 Biotransformation of two citrus flavanones by lactic acid bacteria in chemical defined medium
6 4-n-nonylphenol degradation by the genus Metarhizium with cytochrome P450 involvement
7 Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: the role of aldehyde dehydrogenase. Pharmacol Rev. 2007 Jun;59(2):125-50.
8 Membrane bound catechol-O-methytransferase is the dominant isoform for dopamine metabolism in PC12 cells and rat brain
9 DrugBank(Pharmacology-Metabolism)Levodopa
10 Metabolism of a new orally active dopamine prodrug, N-(N-acetyl-L-methionyl)-O,O-bis(ethoxycarbonyl)dopamine (TA-870) and dopamine after oral administration to rats and dogs
11 Catabolism of L-phenylalanine and L-tyrosine by Rhodobacter sphaeroides OU5 occurs through 3,4-dihydroxyphenylalanine Res Microbiol. 2007 Jul-Aug;158(6):506-11. doi: 10.1016/j.resmic.2007.04.008.

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