Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009229)
Formula
SVG example
N-dealkylation
Reactant Ebastine Product Deslakylebastine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009228 Ebastine 4-(4-tert-butylphenyl)-4-oxobutanal Oxidation - N-dealkylation Ebastine [1]
MR009225 Ebastine Ebastine Metabolite M-5c Unclear - Unclear Ebastine [2]
MR009218 Ebastine Hydroxy-ebastine Oxidation - Hydroxylation Ebastine [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003703 LAS-X-113 Desalkylebastine Oxidation - N-Dealkylation LAS-X-113 [3]
MR009221 Carebastine Deslakylebastine Oxidation - N-dealkylation Ebastine [3]
References
1 Involvement of CYP2J2 and CYP4F12 in the metabolism of ebastine in human intestinal microsomes
2 Identification of rat faecal metabolites of ebastine by B/E linked scanning liquid secondary ion mass spectrometry
3 Characterization of ebastine, hydroxyebastine, and carebastine metabolism by human liver microsomes and expressed cytochrome P450 enzymes: major roles for CYP2J2 and CYP3A. Drug Metab Dispos. 2006 Nov;34(11):1793-7.

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