Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009225)
Formula Reactant Ebastine Product Ebastine Metabolite M-5c
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009228 Ebastine 4-(4-tert-butylphenyl)-4-oxobutanal Oxidation - N-dealkylation Ebastine [1]
MR009229 Ebastine Deslakylebastine Oxidation - N-dealkylation Ebastine [1]
MR009218 Ebastine Hydroxy-ebastine Oxidation - Hydroxylation Ebastine [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009226 Ebastine Metabolite M-5c Ebastine Metabolite M-4 Unclear - Unclear Ebastine [3]
References
1 Involvement of CYP2J2 and CYP4F12 in the metabolism of ebastine in human intestinal microsomes
2 Characterization of ebastine, hydroxyebastine, and carebastine metabolism by human liver microsomes and expressed cytochrome P450 enzymes: major roles for CYP2J2 and CYP3A. Drug Metab Dispos. 2006 Nov;34(11):1793-7.
3 Identification of rat faecal metabolites of ebastine by B/E linked scanning liquid secondary ion mass spectrometry

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