Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009218)
Formula
CYP2J2 ...
SVG example
Hydroxylation
Reactant Ebastine Product Hydroxy-ebastine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2J2 (CYP2J2) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009228 Ebastine 4-(4-tert-butylphenyl)-4-oxobutanal Oxidation - N-dealkylation Ebastine [1]
MR009229 Ebastine Deslakylebastine Oxidation - N-dealkylation Ebastine [1]
MR009225 Ebastine Ebastine Metabolite M-5c Unclear - Unclear Ebastine [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009219 Hydroxy-ebastine Carebastine Unclear - Unclear Ebastine [3], [4]
MR009222 Hydroxy-ebastine Ebastine Metabolite M-4 Conjugation - Mono-methylation Ebastine [2]
MR009227 Hydroxy-ebastine Ebastine Metabolite M-5a Unclear - Unclear Ebastine [2]
References
1 Involvement of CYP2J2 and CYP4F12 in the metabolism of ebastine in human intestinal microsomes
2 Identification of rat faecal metabolites of ebastine by B/E linked scanning liquid secondary ion mass spectrometry
3 Comparative pharmacokinetics of the histamine H1-receptor antagonist ebastine and its active metabolite carebastine in rats, guinea pigs, dogs and monkeys
4 Characterization of ebastine, hydroxyebastine, and carebastine metabolism by human liver microsomes and expressed cytochrome P450 enzymes: major roles for CYP2J2 and CYP3A. Drug Metab Dispos. 2006 Nov;34(11):1793-7.

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