Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009228)
Formula
SVG example
N-dealkylation
Reactant Ebastine Product 4-(4-tert-butylphenyl)-4-oxobutanal
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009229 Ebastine Deslakylebastine Oxidation - N-dealkylation Ebastine [1]
MR009225 Ebastine Ebastine Metabolite M-5c Unclear - Unclear Ebastine [2]
MR009218 Ebastine Hydroxy-ebastine Oxidation - Hydroxylation Ebastine [3]
References
1 Involvement of CYP2J2 and CYP4F12 in the metabolism of ebastine in human intestinal microsomes
2 Identification of rat faecal metabolites of ebastine by B/E linked scanning liquid secondary ion mass spectrometry
3 Characterization of ebastine, hydroxyebastine, and carebastine metabolism by human liver microsomes and expressed cytochrome P450 enzymes: major roles for CYP2J2 and CYP3A. Drug Metab Dispos. 2006 Nov;34(11):1793-7.

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