Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009582)
Formula
CYP2C8 ...
SVG example
Hydroxylation
Reactant Rosiglitazone Product Para-Hydroxyrosiglitazone
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009576 Rosiglitazone N-Desmethylrosiglitazone Oxidation - N-demethylation Rosiglitazone [1]
MR009590 Rosiglitazone N-Despyridinyl rosiglitazone Unclear - Unclear Rosiglitazone [1]
MR009586 Rosiglitazone Ortho-Hydroxyrosiglitazone Oxidation - Hydroxylation Rosiglitazone [1]
MR009591 Rosiglitazone Phenoxyacetic acid derivative of rosiglitazone Oxidation - N-oxidation Rosiglitazone [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009583 Para-Hydroxyrosiglitazone N-Desmethyl-para-hydroxy rosiglitazone Oxidation - N-demethylation Rosiglitazone [1]
MR009585 Para-Hydroxyrosiglitazone Para-O-Glucuronide rosiglitazone Conjugation - Glucuronidation Rosiglitazone [1]
MR009584 Para-Hydroxyrosiglitazone Para-O-Sulfate rosiglitazone Oxidation - Sulfonation Rosiglitazone [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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