Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009614)
Formula Reactant BAF-312 Product Siponimod M7
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009621 BAF-312 Siponimod M1 Unclear - Unclear BAF-312 [1]
MR009622 BAF-312 Siponimod M17 Unclear - Unclear BAF-312 [1]
MR009611 BAF-312 Siponimod M2 Unclear - Unclear BAF-312 [1]
MR009618 BAF-312 Siponimod M5 Oxidation - Hydroxylation BAF-312 [1]
MR009616 BAF-312 Siponimod M6 Oxidation - Hydroxylation BAF-312 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009615 Siponimod M7 Siponimod M4b Oxidation - Sulfonation BAF-312 [1]
References
1 Metabolism and disposition of siponimod, a novel selective S1P1/S1P5 agonist, in healthy volunteers and in vitro identification of human cytochrome P450 enzymes involved in its oxidative metabolism. Drug Metab Dispos. 2018 Jul;46(7):1001-1013.

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