Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009637)
Formula
SVG example
Oxidation
Reactant Tretinoin Product 3,4-Didehydroretinoic acid
Reactant Info Product Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009631 Tretinoin 13-cis RA Other reaction - Isomerization Tretinoin [1], [2]
MR009636 Tretinoin 18-OH-RA Oxidation - Hydroxylation Tretinoin [3], [2], [1]
MR009626 Tretinoin 4-Hydroxyretinoic acid Oxidation - 4-hydroxylation Tretinoin [3], [1]
MR009629 Tretinoin 5,6-epoxy-RA Oxidation - Ring epoxidation Tretinoin [2], [2], [3]
MR009634 Tretinoin 9-cis RA Other reaction - Isomerization Tretinoin [1], [2]
MR009638 Tretinoin Retinotaurine Oxidation - Oxidation Tretinoin [4]
MR009639 Tretinoin Retinoyl beta-glucuronide Conjugation - Glucuronidation Tretinoin [4]
References
1 Human cytochrome P450s involved in the metabolism of 9-cis- and 13-cis-retinoic acids
2 Retinoic acid metabolism and mechanism of action: a review
3 Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. Mol Pharmacol. 2000 Dec;58(6):1341-8.
4 Clinical pharmacokinetics of tretinoin

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