Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009629)
Formula
CYP2C8 ...
SVG example
Ring epoxidation
Reactant Tretinoin Product 5,6-epoxy-RA
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Cytochrome P450 2A6 (CYP2A6) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 1A1 (CYP1A1) DME Info
Metabolic Type Oxidation - Ring epoxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009631 Tretinoin 13-cis RA Other reaction - Isomerization Tretinoin [1], [2]
MR009636 Tretinoin 18-OH-RA Oxidation - Hydroxylation Tretinoin [3], [2], [1]
MR009637 Tretinoin 3,4-Didehydroretinoic acid Oxidation - Oxidation Tretinoin [4]
MR009626 Tretinoin 4-Hydroxyretinoic acid Oxidation - 4-hydroxylation Tretinoin [3], [1]
MR009634 Tretinoin 9-cis RA Other reaction - Isomerization Tretinoin [1], [2]
MR009638 Tretinoin Retinotaurine Oxidation - Oxidation Tretinoin [4]
MR009639 Tretinoin Retinoyl beta-glucuronide Conjugation - Glucuronidation Tretinoin [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006382 NSC-122758 5,6-Epoxyretinoic acid Unclear NSC-122758 [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009630 5,6-epoxy-RA Rac-5,6-Epoxy-retinoyl-beta-D-glucuronide Conjugation - Glucuronidation Tretinoin [4]
References
1 Human cytochrome P450s involved in the metabolism of 9-cis- and 13-cis-retinoic acids
2 Retinoic acid metabolism and mechanism of action: a review
3 Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. Mol Pharmacol. 2000 Dec;58(6):1341-8.
4 Clinical pharmacokinetics of tretinoin

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