Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009785)
Formula
CYP3A4 ...
SVG example
O-dealkylation
Reactant AST-1306 Product Allitinib M1
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 2E1 (CYP2E1) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - O-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009797 AST-1306 Allitinib M10 Unclear - Unclear AST-1306 [1]
MR009795 AST-1306 Allitinib M14 Unclear - Unclear AST-1306 [1]
MR009799 AST-1306 Allitinib M2 Unclear - Unclear AST-1306 [1]
MR009792 AST-1306 Allitinib M6 Unclear - Unclear AST-1306 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009786 Allitinib M1 Allitinib M3 Oxidation - Hydroxylation AST-1306 [1]
MR009790 Allitinib M1 Allitinib M4 Unclear - Unclear AST-1306 [1]
MR009791 Allitinib M1 Allitinib M5 Unclear - Unclear AST-1306 [1]
MR009788 Allitinib M1 Allitinib M9 Unclear - Unclear AST-1306 [1]
References
1 Metabolism and pharmacokinetics of allitinib in cancer patients: the roles of cytochrome P450s and epoxide hydrolase in its biotransformation

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