Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010020)
Formula
SVG example
DemethylationHydroxylation
Reactant Quinine sulfate Product Quinine sulfate Metabolite M2
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Multi-steps Reaction - DemethylationHydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010024 Quinine sulfate 10, 11-Dihydroxydihydroquinine Unclear - Unclear Quinine sulfate [1]
MR010023 Quinine sulfate 2'-oxoquininone Unclear - Unclear Quinine sulfate [2]
MR010021 Quinine sulfate 3-hydroxyquinine Unclear - Unclear Quinine sulfate [2], [3], [4]
MR010022 Quinine sulfate N-oxidequinine Unclear - Unclear Quinine sulfate [2]
MR010016 Quinine sulfate Quinine sulfate Metabolite M1 Oxidation - Hydroxylation Quinine sulfate [5]
MR010018 Quinine sulfate Quinine sulfate Metabolite M3 Oxidation - Demethylation Quinine sulfate [5]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010017 Quinine sulfate Metabolite M1 Quinine sulfate Metabolite M2 Unclear - Unclear Quinine sulfate [5]
MR010019 Quinine sulfate Metabolite M3 Quinine sulfate Metabolite M2 Unclear - Unclear Quinine sulfate [5]
References
1 Alteration of the Disposition of Quinine in Healthy Volunteers After Concurrent Ciprofloxacin Administration
2 Metabolism of quinine in man: identification of a major metabolite, and effects of smoking and rifampicin pretreatment
3 Effects of Plasmodium falciparum infection on the pharmacokinetics of quinine and its metabolites in pregnant and non-pregnant Sudanese women
4 Rapid quantification of quinine and its major metabolite (3S)-3-hydroxyquinine in diluted urine by UPLC-MS/MS
5 CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: a possible metabolic link to blackwater fever

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