Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010021)
Formula
SVG example
Unclear
Reactant Quinine sulfate Product 3-hydroxyquinine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010024 Quinine sulfate 10, 11-Dihydroxydihydroquinine Unclear - Unclear Quinine sulfate [1]
MR010023 Quinine sulfate 2'-oxoquininone Unclear - Unclear Quinine sulfate [2]
MR010022 Quinine sulfate N-oxidequinine Unclear - Unclear Quinine sulfate [2]
MR010016 Quinine sulfate Quinine sulfate Metabolite M1 Oxidation - Hydroxylation Quinine sulfate [3]
MR010020 Quinine sulfate Quinine sulfate Metabolite M2 Multi-steps Reaction - DemethylationHydroxylation Quinine sulfate [3]
MR010018 Quinine sulfate Quinine sulfate Metabolite M3 Oxidation - Demethylation Quinine sulfate [3]
References
1 Alteration of the Disposition of Quinine in Healthy Volunteers After Concurrent Ciprofloxacin Administration
2 Metabolism of quinine in man: identification of a major metabolite, and effects of smoking and rifampicin pretreatment
3 CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: a possible metabolic link to blackwater fever

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