Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010268)
Formula Reactant Lumateperone tosylate Product IC200565
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-desmethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR014071 Lumateperone tosylate IC200161 Oxidation - Dealkylation lumateperone tosylate [1]
MR010266 Lumateperone tosylate ICI200131 Unclear - Unclear lumateperone tosylate [2]
MR014073 Lumateperone tosylate ICI200131 Reduction - Reduction lumateperone tosylate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011409 ITI-007 IC200565 Oxidation - Dealkylation ITI-007 [2]
References
1 Dopamine D(2) receptor occupancy of lumateperone (ITI-007): a Positron Emission Tomography Study in patients with schizophrenia
2 An evaluation of lumateperone tosylate for the treatment of schizophrenia

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